Results
| PMID | 20553681 |
| Gene Name | FSHB |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 77 |
| Population details | 77 (27 were infertile and had endometriosis, 50 controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | FSH |
| Other associated phenotypes |
Endometriosis associated infertility |
|
Int J Gynaecol Obstet. 2010 Sep;110(3):208-12. doi: 10.1016/j.ijgo.2010.03.033. de Carvalho, Bruno Ramalho| Rosa-e-Silva, Ana Carolina Japur de Sa| Rosa-e-Silva, Julio Cesar| dos Reis, Rosana Maria| Ferriani, Rui Alberto| Silva-de-Sa, Marcos Felipe Service of Human Reproduction, Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil. bruno@genesis.med.br OBJECTIVE: To determine whether basal levels of follicle-stimulating hormone (FSH) and anti-mullerian hormone (AMH), antral follicle count (AFC), and the numbers of dominant follicles, oocytes, and mature oocytes retrieved after ovarian stimulation differed between infertile women with endometriosis and healthy women undergoing assisted reproduction techniques (ART). METHOD: Of 77 consecutive ART candidates, 27 were infertile and had endometriosis. A male factor caused the infertility of the other 50, who acted as controls. RESULTS: The AMH and AFC levels were similar in the 2 groups. The FSH levels were higher (8.28 mIU/mL [range, 5.25-24.1 mIU/mL] vs 5.91 mIU/mL [range, 2.47-18.7 mIU/mL]; P<0.01) in the study group. And the numbers of retrieved (n=5 [range, 0-12] vs n=9 [range, 0-27; P<0.05) and mature oocytes (n=4 [range, 0-11] vs n=5 [range, 0-16]; P<0.05) were less in the study group. CONCLUSION: Because AMH levels were unchanged, endometriosis seems not to damage the primordial pool of follicles and oocytes, but to lessen the quality of the ovarian response to the hCG injection. Basal FSH levels may be of value in predicting ART success in women with the disease. Mesh Terms: Adult| Anti-Mullerian Hormone/*blood| Case-Control Studies| Cell Count| Endometriosis/blood/complications/*pathology| Female| Follicle Stimulating Hormone/*blood| Humans| Infertility, Female/blood/complications/*pathology/therapy| Male| Oocytes/ |
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